Research Articles
Orthogonality in Synthetic Gene Circuit Design: Principles for Robust, Predictable, and Evolutionarily Stable Genetic Systems
This article provides a comprehensive overview of orthogonality as a foundational principle in synthetic gene circuit design, tailored for researchers and drug development professionals.
Functional Genetic Circuit Screening: Advanced Methods for Biomedical Discovery and Therapeutic Development
This article provides a comprehensive overview of modern screening methodologies for functional genetic circuits, targeting researchers, scientists, and drug development professionals.
Managing Genetic Context Effects in Circuit Design: Strategies for Robust and Predictable Synthetic Biology
The predictable design of synthetic gene circuits is fundamentally challenged by genetic context effects, where circuit performance is unpredictably modulated by interactions with the host cell.
Synthetic Transcription Factors: Engineering Gene Control for Therapy and Research
Synthetic transcription factors (synTFs) are engineered proteins that enable precise control over gene expression, offering revolutionary potential for cell reprogramming, gene therapy, and functional genomics.
T-Pro Transcriptional Programming: A Comprehensive Guide for Predictive Genetic Circuit Design
This guide provides researchers, scientists, and drug development professionals with a comprehensive overview of Transcriptional Programming (T-Pro), a synthetic biology framework for designing compressed genetic circuits.
CRISPR Synthetic Biology: Revolutionizing Therapeutic Development from Discovery to Clinic
This article provides a comprehensive overview of CRISPR synthetic biology, detailing its foundational principles derived from prokaryotic immune systems and its transformative role in modern drug discovery and development.
Genome Mining for Natural Products: A Data-Driven Blueprint for Novel Drug Discovery
This article provides a comprehensive overview for researchers and drug development professionals on leveraging genome mining for natural product discovery.
HITI Revolution: Mastering Homology-Independent Targeted Integration for Advanced Gene Therapies
This article provides a comprehensive exploration of Homology-Independent Targeted Integration (HITI), a groundbreaking CRISPR/Cas9-based genome editing technology that leverages the non-homologous end joining (NHEJ) pathway.
Automating Discovery: How Robotic Platforms and AI Are Revolutionizing the Design-Build-Test-Learn Cycle in Drug Development
This article explores the transformative integration of robotic platforms and artificial intelligence in automating the Design-Build-Test-Learn (DBTL) cycle for biomedical research and drug development.
From Molecules to Networks: Mathematical Modeling Approaches for Decoding Cellular Organization in Systems Biology
This article provides a comprehensive overview of mathematical modeling approaches used to understand the complex organization of cells, from intracellular signaling to multicellular structures.