Research Articles
T-Pro Transcriptional Programming: A Comprehensive Guide for Predictive Genetic Circuit Design
This guide provides researchers, scientists, and drug development professionals with a comprehensive overview of Transcriptional Programming (T-Pro), a synthetic biology framework for designing compressed genetic circuits. It covers the foundational principles of T-Pro, detailing its orthogonal synthetic transcription factors and promoters. The article explores advanced methodologies for constructing multi-input Boolean logic circuits, strategies for troubleshooting and optimizing circuit performance to minimize cellular burden, and comparative validation techniques to ensure predictive accuracy. By integrating wetware development with complementary software tools, this resource serves as a practical guide for engineering efficient cellular programs for biomedical research and therapeutic applications.
The Third Pathway: How a Biochemical Curiosity Became a Medical Game-Changer
Discover how the arachidonic acid monooxygenase pathway evolved from biochemical curiosity to medical breakthrough in treating hypertension, heart disease, and cancer.
The Presidential Formula: Can Science Predict the Oval Office?
Explore how scientific prediction models have accurately forecasted presidential elections and what makes a president historically great.
Engineering Life: Designing Proteins to Build Synthetic Cells
Explore how custom-designed proteins are revolutionizing synthetic biology and enabling the creation of artificial cells for medicine, energy, and environmental solutions.
The Future of Addiction Psychiatry: How Science is Rewriting the Story of Addiction
Explore the scientific revolution transforming addiction psychiatry through neuroscience, technology, and human compassion.
Golden Hope Against Superbugs: How Plant-Made Nanoparticles Fight Infections Safely
Discover how gold nanoparticles synthesized with FDM29 and Baissea gracillima show promising antimicrobial effects with reduced toxicity in zebrafish embryos.
Turning Over a New Leaf: How Materials Science is Revolutionizing Pest Control
Discover how materials science is creating innovative, sustainable pest control solutions inspired by nature's own defense mechanisms.
The Scaffold Revolution: Rebuilding Teeth from the Inside Out
Explore scaffold-based regenerative endodontics, a revolutionary approach to dental care that regenerates living tooth tissue instead of traditional fillings.
Lighting the Way: How N-Amino Pyridinium Salts Are Revolutionizing Photochemistry
Discover how N-amino pyridinium salts are transforming photochemistry, enabling precise molecular construction and solving long-standing C3-amination challenges.
The Invisible Arms Race: When AI Meets Synthetic Biology
Exploring the security implications of Synthetic Biology and AI convergence (SynBioAI) - the emerging threats and regulatory challenges in frontier science